PE-22-28 Prices

Also known as Spadin analog; TREK-1 blocker

18 listings from 16 vendors, normalised to one honest price per milligram.

Cheapest per mg
$3.96/mg
At
Fusion Peptide
Vendors
16
Sizes
8mg, 10mg, 10mg Kit (10 vials)

PE-22-28 price per mg by vendor

Prices last collected October 3, 2026. Prices change often - check the vendor's site before ordering.

Choose a size to compare vendor prices.

Mixing PE-22-28

What each amount of water produces at this vial size. Educational reference, not a recommendation.

4 mL2.00 mg/mL50 mcg = 2.5 units
5 mL1.60 mg/mL50 mcg = 3.13 units
3.5 mL2.29 mg/mL50 mcg = 2.19 units

Vial sizes are the ones vendors list for PE-22-28. Syringe marks assume a 50 mcg dose on a U-100 syringe, taken from this compound's reference range. Work out any other combination in the reconstitution calculator.

About PE-22-28

What it is
PE-22-28 is a synthetic seven amino acid peptide derived from spadin, a fragment of the sortilin propeptide. In rodent and laboratory studies it blocks the TREK-1 potassium channel with high potency and produced antidepressant-like effects along with signs of increased hippocampal neurogenesis. It has not been tested in humans and remains an investigational research compound.
How it works
It inhibits the TREK-1 potassium channel, an action linked in animal models to antidepressant effects and enhanced neurogenesis.
Researched for
Depression research; neurogenesis research; TREK-1 studies
Half-life
Not established in humans
Familiarity
Advanced
Research evidence
Animal studies only
Regulatory status
Preclinical
Key risk
None documented
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Disclosure. Some vendors above are Peptul partners and pay us a commission when you buy through our link. Rows are ordered by: Peptul partners first, then what is in stock, then single vials before multi-vial packs, then price per milligram. Paying us moves a vendor up this order and changes nothing else - not their trust tier, COA badge, Peptul Score or reviews, which come from evidence and are worked out the same way for everyone. Available discount codes are shown beside the prices above. Discounted prices require the displayed code where indicated.

For educational and research purposes only. Not medical advice. Always consult a qualified healthcare provider before using any research compound.