Gut Health
Research compounds studied for gut lining repair, intestinal permeability reduction, and inflammatory bowel conditions. Many effective via oral route - no injections required.
Most researched for Gut Health
BPC-157
The most referenced gut healing peptide with a unique advantage: it survives digestion and acts directly on the gut lining when taken orally. Research shows accelerated healing of gastric ulcers, intestinal fistulas, and IBD-related damage. The oral route makes it the most accessible entry point for gut health research - no injections needed for gut-specific applications.
BPC-157
aka Body Protection Compound-157, PL 14736
How it works: Upregulates growth factor receptors and promotes angiogenesis to accelerate soft tissue repair.
Tendon, ligament, muscle, bone healing; GI tract repair; wound healing
Dosage range
200-500 mcg, Once or twice daily
Administration
SubQ / IM / Oral / Intranasal
Timing
Morning fasted or near injury site
Cycle length
4-12 weeks
KPV
aka Lys-Pro-Val, alpha-MSH C-terminal tripeptide
How it works: Blocks NF-kB inflammatory signaling pathways to reduce chronic inflammation.
GI inflammation; IBD/Crohn's; leaky gut; systemic anti-inflammatory
Dosage range
250-1000 mcg, Once or twice daily
Administration
SubQ / Oral
Timing
Any time
Cycle length
4–8 weeks
Larazotide Acetate
aka AT-1001, Larazotide, AT-1001, INN-202
How it works: Directly tightens intestinal tight junctions to reduce leaky gut and prevent passage of antigens.
Leaky gut reduction; celiac adjunct; intestinal barrier restoration
Dosage range
0.25-2 mg, 3×/day before meals
Administration
Oral
Timing
Before each meal
Cycle length
8–12 weeks
LL-37
aka Cathelicidin, Cathelicidin, CAMP
How it works: An antimicrobial host defense peptide that kills pathogens directly and recruits immune cells to sites of infection.
Antimicrobial (bacteria, fungi, viruses); immune modulation; wound healing
Dosage range
0.1-1 mg, Variable; 1–3×/day or every other day
Administration
SubQ / Topical
Timing
Any time
Cycle length
4–8 weeks
BPC-157 Oral Capsules
aka Oral BPC-157, BPC-157 capsules
How it works: Oral BPC-157 survives gastric acid (gastric protein origin); local GI mucosal effects + some systemic absorption; upregulates VEGF/EGF locally in GI; anti-inflammatory mucosal
GI tract healing (primary); gastric ulcer; IBD; leaky gut; esophageal repair
Dosage range
500-1000 mcg, Once or twice daily (oral)
Administration
Oral
Timing
Fasted for systemic attempt; with meals for GI mucosal targeting
Cycle length
4–12 weeks
VIP
aka Vasoactive Intestinal Peptide, Vasoactive Intestinal Peptide
How it works: Binds VPAC1 and VPAC2 receptors; vasodilation; bronchodilation; immunomodulation (anti-inflammatory in some contexts); GI secretion; CNS neuroprotection; circadian regulation
POTS/dysautonomia (emerging); mast cell activation; pulmonary arterial hypertension (VPAC agonism); immune modulation
Dosage range
50-200 pmol/kg/min (IV); or 50–200 mcg SubQ, Variable by indication
Administration
SubQ / IV (clinical)
Timing
Any time
Cycle length
Per protocol
Example stacks
Gut Health - Beginner
Oral BPC-157 is the most accessible gut healing protocol - no injection required. Survives digestion and acts directly on the gut lining.
- • Take on empty stomach - 30 min before food or 2 hrs after
- • Keep a symptom diary
- • Be patient - improvements start at 3-4 weeks
Gut Health - Intermediate
BPC-157 repairs the gut lining while KPV targets inflammatory signaling. Both oral - a fully injectable-free protocol.
- • Take BPC-157 fasted and KPV any time
- • KPV is especially useful for IBD and autoimmune component
- • Eliminate known dietary triggers
Community outcome data
Collected from users researching this goal. Not a clinical database - for general reference only.
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