Sexual Health & Libido
Research compounds studied for central arousal pathways, hormonal axis restoration, and sexual response enhancement. Includes FDA-approved compounds and hormonal modulators.
Most researched for Sexual Health & Libido
PT-141
The only compound in this category with FDA approval for a sexual health indication (female hypoactive sexual desire disorder under the name Vyleesi). PT-141 activates melanocortin receptors in the brain to increase sexual desire centrally - a distinct mechanism from PDE5 inhibitors (Viagra/Cialis) which work peripherally. On-demand dosing, fast onset, validated across genders in clinical research.
Bremelanotide
aka PT-141, PT-141, Vyleesi
How it works: Activates melanocortin receptors in the brain to increase sexual desire via central nervous system pathways.
Female HSDD (FDA-approved Vyleesi); male ED (off-label); libido enhancement
Dosage range
1-1.75 mg, As needed; max 1/24h; max 8/month (FDA label)
Administration
SubQ (approved); intranasal (off-label)
Timing
30–45 min before sexual activity
Cycle length
As needed
Melanotan II
aka MT-2, MT-II
How it works: Activates melanocortin receptors to stimulate melanin production, providing UV-induced pigmentation and some photoprotection.
Skin tanning/pigmentation; libido enhancement; erectile function
Dosage range
250-1000 mcg, Daily (loading) then maintenance 2–3×/week
Administration
SubQ
Timing
Evening (nausea management)
Cycle length
Loading 1–2 wks; maintenance ongoing (with UV exposure for tanning)
Kisspeptin-10
aka KP-10, Metastin (45-54)
How it works: Stimulates hypothalamic GnRH pulses to restore the hormonal axis and increase baseline testosterone and estrogen levels.
LH pulse stimulation; testosterone elevation; reproductive axis activation; fertility support
Dosage range
0.3-3 mcg/kg, Pulsatile: every 90 min (physiological); practical: 1–2 ×/day SubQ
Administration
SubQ / IV (clinical)
Timing
Morning and/or pre-sleep
Cycle length
Cyclical use; 2–4 wks on; break
Gonadorelin
aka GnRH, LH-RH, Factrel
How it works: Identical to endogenous GnRH; pulsatile administration stimulates LH/FSH; continuous administration paradoxically suppresses LH/FSH (see triptorelin for suppression use)
LH and FSH stimulation; testicular function maintenance during TRT; post-cycle fertility support
Dosage range
100-500 mcg, Pulsatile: every 90–120 min (physiological); practical: 2×/day SubQ
Administration
SubQ / IM / Intranasal
Timing
Morning + evening (practical pulsatile approximation)
Cycle length
Ongoing (TRT adjunct); or 4–8 wks (fertility/PCT)
Nafarelin
aka Synarel
How it works: GnRH agonist → initial LH/FSH flare → continuous use downregulates receptors → medical hormone suppression; intranasal differentiates from injectable GnRH analogs
Endometriosis (FDA); central precocious puberty (FDA); menstrual cycle control
Dosage range
200-400 mcg, Twice daily intranasal (Synarel label)
Administration
Intranasal
Timing
Twice daily (AM + PM)
Cycle length
6 months max per FDA label
Triptorelin
aka Decapeptyl, Trelstar, D-Trp6-LHRH
How it works: GnRH agonist — PULSATILE = stimulates LH/FSH; CONTINUOUS = downregulates GnRH receptors → suppresses testosterone (used for prostate cancer). PCT use: single low dose to restart HPG axis.
Post-cycle therapy (PCT) hormonal restart; testosterone recovery after anabolic steroid use
Dosage range
100-500 mcg, PCT: SINGLE DOSE only (one injection); medical: depot injection q1–3 months
Administration
SubQ / IM / SC depot
Timing
PCT: single injection timing varies by protocol
Cycle length
PCT: single dose, then wait for HPG restart; medical: chronic
Oxytocin
aka Pitocin, OT
How it works: Activates oxytocin receptors in the brain to enhance social bonding, emotional connection, and intensity of sexual response.
Social bonding; trust; intimacy; sexual arousal; orgasm intensity enhancement
Dosage range
20-40 IU, As needed; intranasal or SubQ
Administration
Intranasal (most practical); SubQ (research); IV (medical obstetrics only)
Timing
20–45 min before desired effect
Cycle length
As needed (not cycled)
Example stacks
Libido - Beginner
PT-141 on-demand is the simplest and most validated starting point. FDA-approved for female sexual dysfunction.
- • Start at 0.5 mg and assess before moving to 1 mg
- • Allow the full 1-2 hr onset window
- • Inject in the abdomen or thigh
Libido - Intermediate
Kisspeptin-10 restores baseline hormonal signaling. PT-141 handles on-demand arousal. Addresses both the root hormonal cause and immediate response.
- • Space Kisspeptin evenly - e.g. Mon, Wed, Fri
- • Give Kisspeptin 4+ weeks to show hormonal effects
- • Test testosterone and estrogen before and after the cycle
Community outcome data
Collected from users researching this goal. Not a clinical database - for general reference only.
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